One-Handed Typing, Navigating and Gaming
There are various reasons why you might need one-handed input.
Gamers might use their left hand for cursor movement (āW, A, S, Dā or linear cursor line) and the right hand for the mouse. Of course, in this case, a split keyboard, or at least a small keyboard, saves a lot of space and makes gaming more ergonomic.
Accountants that need to input many numbers could consider such a configuration, but using one hand for a keyboard with a number block and basic editing commands (TAB, copy/paste, etc.), and a mouse.
Finally, one hand could be temporarily or permanently disabled, e.g., after an accident or because of a disease. In this case, all symbols and commands are ideally available on one hand with little movement. You can realize this with one half of a split keyboard, e.g., a Kyria keyboard with a large thumb cluster. One of the keys can be programmed to switch the layer to make the other side of the keyboard available.
QMK swap hands feature